BindingDB BDBM7461 5,7-dihydroxy-2-phenyl-4H-chromen-4-one::5,7-dihydroxy-2-phenyl-chromen-4-one::5,7-dihydroxyflavone::CHEMBL117::chrysin::cid

BDBM7461 5,7-dihydroxy-2-phenyl-4H-chromen-4-one::5,7-dihydroxy-2-phenyl-chromen-4-one::5,7-dihydroxyflavone::CHEMBL117::chrysin::cid_5281607

SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1

InChI Key InChIKey=RTIXKCRFFJGDFG-UHFFFAOYSA-N

Data 21 KI 57 IC50 1 Kd 1 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7461

Mitogen-activated protein kinase 10(Homo sapiens (Human))
Eberhard Karls University of Tuebingen

BDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)

IC50: 1.18E+4nMT: 2°CAssay Description:The p38alpha reaction was carried out by using kinase (12ng per well), ATP (100uM) and incubated for 60 min at 37 C. For the JNK3 assay, kinase (10n...More data for this Ligand-Target Pair

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Filter my 80 hits

Targets 50▿
- Neuraminidase 5
- Cytochrome P450 1B1 4
- Cytochrome P450 1A2 4
- Integrase 3
- Carbonic anhydrase 12 3
- Cytochrome P450 1A1 3
- Carbonic anhydrase 1 3
- Aromatase 3
- Carbonic anhydrase 2 3
- Aldo-keto reductase family 1 member B1 2
- Xanthine dehydrogenase/oxidase 2
- Carbonyl reductase [NADPH] 1 2
- Broad substrate specificity ATP-binding cassette transporter ABCG2 2
- Proteasome subunit beta type-5 2
- Carbonic anhydrase 9 2
- Serine/threonine-protein kinase pim-1 2
- Glycogen synthase kinase-3 beta 2
- Death-associated protein kinase 1 1
- Tyrosine-protein kinase Lck 1
- 3-oxoacyl-acyl-carrier protein reductase 1
- Steroidogenic factor 1 1
- Casein kinase II subunit alpha 3 1
- Cyclin-dependent kinase 6 1
- Nuclear receptor subfamily 0 group B member 1 1
- Sialidase-2 1
- ATP-dependent translocase ABCB1 1
- Dipeptidyl peptidase 3 1
- Calmodulin-1 1
- Aldo-keto reductase family 1 member B1 [K65Q] 1
- Cytochrome P450 2C9 1
- Mitogen-activated protein kinase 14 1
- Cytochrome P450 2A6 1
- Cytochrome P450 3A4 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Cyclin-dependent kinase 5 activator 1 [99-307] 1
- Peroxisome proliferator-activated receptor gamma 1
- DNA gyrase subunit A/B 1
- Prostaglandin G/H synthase 2 1
- Prostaglandin G/H synthase 1 1
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B 1
- Mitogen-activated protein kinase 10 1
- Solute carrier organic anion transporter family member 2B1 1
- Urease subunit beta 1
- Seed linoleate 13S-lipoxygenase-1 1
- Cyclin homolog/dependent kinase 6 1
- Carbonic anhydrase 7 1
- Lactoylglutathione lyase 1
- Cytochrome P450 2D6 1
- Carbonic anhydrase 4 1
- Cytochrome P450 2B6 1
Publications 41▿
- Bioorg Med Chem Lett 22: 3063-6 (2012) 8
- Bioorg Med Chem 23: 7219-25 (2015) 5
- Bioorg Med Chem Lett 20: 6008-12 (2010) 4
- J Med Chem 56: 4082-92 (2013) 4
- J Med Chem 48: 737-43 (2005) 4
- Eur J Med Chem 135: 296-306 (2017) 3
- Bioorg Med Chem 18: 6310-5 (2010) 3
- Bioorg Med Chem 22: 3146-58 (2014) 3
- Bioorg Med Chem 16: 7141-7 (2008) 3
- Chembiochem 11: 2579-88 (2010) 2
- Bioorg Med Chem 19: 2842-9 (2011) 2
- Bioorg Med Chem 19: 2090-102 (2011) 2
- Bioorg Med Chem Lett 24: 77-82 (2014) 2
- Eur J Med Chem 167: 291-311 (2019) 2
- Eur J Med Chem 45: 1724-30 (2010) 2
- Bioorg Med Chem 17: 530-6 (2009) 2
- PubChem Bioassay (2010) 1
- Eur J Med Chem 46: 4078-88 (2011) 1
- Eur J Med Chem 72: 137-45 (2014) 1
- PubChem Bioassay (2013) 1
- J Med Chem 58: 7400-8 (2015) 1
- Bioorg Med Chem Lett 20: 3050-64 (2010) 1
- Bioorg Med Chem 20: 2603-13 (2012) 1
- Bioorg Med Chem 16: 3245-54 (2008) 1
- J Nat Prod 55: 1529-1560 (1992) 1
- J Nat Prod 61: 71-6 (1998) 1
- Bioorg Med Chem 19: 542-6 (2011) 1
- Bioorg Med Chem Lett 21: 1222-6 (2011) 1
- J Med Chem 49: 3345-53 (2006) 1
- Mol Cancer Ther 6: 163-72 (2007) 1
- Chem Biol Drug Des 89: 619-627 (2017) 1
- Bioorg Med Chem Lett 23: 1768-70 (2013) 1
- Bioorg Med Chem 27: 677-685 (2019) 1
- Bioorg Med Chem 15: 6463-73 (2007) 1
- J Med Chem 31: 1396-406 (1988) 1
- Eur J Med Chem 102: 375-86 (2015) 1
- Bioorg Med Chem 18: 3020-5 (2010) 1
- Eur J Med Chem 135: 491-516 (2017) 1
- Bioorg Med Chem 18: 1633-40 (2010) 1
- Eur J Med Chem 63: 685-95 (2013) 1
- PubChem Bioassay (2013) 1
Institutions 38▿
- Universit£ 11
- Aristotle University Of Thessaloniki 5
- Xavier University Of Louisiana 4
- Lawrence Berkeley National Laboratory 4
- Sun Yat-Sen University 4
- University Of Shizuoka 3
- South China Normal University 3
- Peking Union Medical College 3
- Central South University 2
- Eberhard Karls University of Tuebingen 2
- Institute Of Agricultural And Food Biotechnology 2
- Universidad De Buenos Aires 2
- University Of Crete 2
- UniversitäT TüBingen 2
- The Scripps Research Institute Molecular Screening Center 2
- University Of Bonn 2
- Guru Nanak Dev University 2
- Loma Linda University 1
- Johns Hopkins University 1
- Monash University 1
- China Pharmaceutical University 1
- University Of Antwerp 1
- Chosun University 1
- University Of Toyama 1
- Loma Linda University School Of Medicine 1
- Uniroyal Chemical 1
- University Of Nis 1
- Broad Institute 1
- American University Of Ras Al Khaimah 1
- Dongguk University-Seoul 1
- Hokkaido University 1
- TBA 1
- Northern Kentucky University 1
- Universidade Do Porto 1
- University Of Zurich 1
- Josip Juraj Strossmayer University of Osijek 1
- Jishou University 1
- Universidad Aut£Noma Del Estado De Morelos 1
Affinity: 1 to 2.0E+6 nM▿
- Ki 21
- IC50 57
- Kd 1
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 2
Catalog Cmpds: 1